PQ 401

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Cat No.

CEI-0882

Description

PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.

CAS_No

196868-63-0

Molecular Weight

341.79

Storage

2 years -20 centigrade Powder; 2 weeks 4 centigrade in DMSO; 6 months -80 centigrade in DMSO.

Targets

IGF-1R

IC50

<1 μM

Molecular Formula

C18H16ClN3O2

Chemical Name

N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-

Solubility

DMSO 32 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL

In vitro

PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells.

In vivo

PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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