Protein Kinase G Iβ human, Recombinant

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Cat No.

NATE-0580

Description

Protein Kinase G Iβ induces apoptosis in certain cell lines such as human breast cancer cell lines MCF-7 and MDA-MB-468. It inhibits cell proliferation and induces apoptosis in colon cancer cell lines.

Abbr

PKG1B, Recombinant (Human)

Alias

PRKG1B; PRKGR1B; PKG1B

Source

baculovirus infected insect cells

Species

Human

Applications

Protein Kinase G is a serine/threonine-specific protein kinase that is activated by cGMP. Protein Kinase G Iβ is used to induce apoptosis and inhibit cell proliferation.

Product Overview

> 95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution

Form

buffered aqueous glycerol solution

Activity

> 1.5 units/mg protein (20-fold stimulation by cGMP (5 μM))

Molecular Weight

mol wt 76 kDa (monomer)

Purity

>95% (SDS-PAGE)

Unit Definition

One unit will phosphorylate 1 micromole of VASPtide (RRKVSKQE) substrate per minute in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 1 mM DTE and 0.2 mM EDTA.

Stability

−20°C

Buffer

Solution in 20 mM Tris buffer, pH 7.4, 1 mM EDTA, 1 mM β-mercaptoethanol, 100 mM NaCl, 10 U/ml Trasylol, and 50% glycerol.

Pathway

Adaptive Immune System, organism-specific biosystem; Gap junction, organism-specific biosystem; Gap junction, conserved biosystem; Hemostasis, organism-specific biosystem; Immune System, organism-specific biosystem; Long-term depression, organism-specific biosystem; Long-term depression, conserved biosystem

Function

ATP binding; cGMP binding; cGMP-dependent protein kinase activity; calcium channel regulator activity; nucleotide binding; protein binding; protein serine/threonine kinase activity

Synonyms

Protein Kinase G Iβ; PRKG1B; PRKGR1B; PKG1B; cGMP-dependent protein kinase 1; cGKI-BETA

"PKG" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-0581	Protein Kinase G II from rat, Recombinant			baculovirus infected Sf9 cells	Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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