RAF265 (CHIR-265)

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Cat No.

CEI-0170

Description

RAF265 (CHIR-265) can inhibit b-Raf and VEGFR2 with IC50 of 3 nM and 60 nM.

CAS_No

927880-90-8

Molecular Weight

518.41

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

b-Raf, VEGFR2

Molecular Formula

C24H16F6N6O

Chemical Name

1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine

Solubility

DMSO 104 mg/mL Water

In vitro

RAF265 can inihbit RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 uM. Raf265 show inhibition to the growth of advanced human melanoma tumors. Raf265 significantly enhanced TRAIL (tumour-selective death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand) sensitivity in NCI-H727 and CM insulinoma cells. Raf265 strongly decreased Bcl-2 levels in those cell lines susceptible to its TRAIL-sensitizing action by blocking Raf-MEK-Erk signaling.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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