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Enzymes for Research, Diagnostic and Industrial Use

Renin from Human, Recombinant

Cat No.
NATE-1951
Description
Renin, also known as an angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin aldosterone system (RAAS)—also known as the renin-angiotensin-aldosterone axis—that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure. Renin is often improperly referred to as a hormone even though it has no peripheral receptors and rather has an enzymatic activity with which it hydrolyses angiotensinogen to angiotensin I.
Source
HEK cells, Mature Renin (aa 67-406) is fused at the N-terminus to a FLAG-tag. Active form, does not contain prorenin peptide (aa 1-66).
Species
Human
Form
Lyophilized. In 25mM MES buffer containing 150mM NaCl.
Enzyme Commission Number
EC 3.4.23.15
Activity
>30U/mg
CAS No.
9015-94-5
Molecular Weight
~52kDa (predicted is 38.3 kDa)
Purity
>90%
Concentration
0.1 mg/ml when reconstituted as suggested.
Unit Definition
1 unit is defined as the amount of enzyme that cleaves 1 pmole of the fluorogenic peptide substrate, Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg.
Stability
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Storage
at -20°C
Preparation Instructions
Reconstitute in 100µl deionized H2O for a final concentration of 0.1mg/ml.
Synonyms
REN; HNFJ2; Renin; angiotensinogenase; Angiotensin forming enzyme
Endotoxin Level
<0.1EU/µg protein (LAL test)
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