Rocaglamide

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Cat No.

CEI-0589

Description

An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.

Alias

Rocaglamide A

Appearance

White solid

Product Overview

An immunosuppressant

CAS_No

84573-16-0

Molecular Weight

228.2

Purity

>98% by HPLC

Storage

-20 centigrade

Synonyms

Rocaglamide A

Targets

NFKB1

Molecular Formula

C₂₉H₃₁NO₇

Solubility

DMSO (100 mM) or H2O (100 mM)

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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