Roscovitine (Seliciclib,CYC202)

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Cat No.

CEI-0292

Description

Roscovitine can inhibit p33 cdk2/p35, p34 cdc2/cyclin B, p33 CDK2/cyclin A, and p33 CDK2/cyclin E with IC50 of 200 nM, 650 nM, 700 nM, and 700 nM.

CAS_No

186692-46-6

Molecular Weight

354.45

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

p33 cdk2/p35, p34 cdc2/cyclin B, p33 CDK2/cyclin A, p33 CDK2/cyclin E

Molecular Formula

C19H26N6O

Chemical Name

(R)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol

Solubility

DMSO 71 mg/mL Water

In vitro

As an ATP competitive inhibitor, roscovitine can inhibit p33 cdk2/p35, p34 cdc2/cyclin B, p33 CDK2/cyclin A, and p33 CDK2/cyclin E with IC50 of 200 nM, 650 nM, 700 nM, and 700 nM. When combined with DNA damaging agents, R-Roscovitine was able to prevent the DNA damage-induced upregulation of cyclin A1 on a transcriptional and post-transcriptional level. Roscovitine can induce apoptosis in MCF-7 cell line. After roscovitine treatment, the level of wild-type p53 protein strongly increased and p53 was accumulated in the nucleus.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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