Rotenone

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Cat No.

CEI-0571

Description

A broad spectrum insecticide that is cell-permeable and brain-permeable. Acts as a mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 µM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Neurotoxic agent that has also been used successfully to reproduce Parkinsons-like characteristics in in-vitro slice culture models.

Appearance

White to off-white solid

Product Overview

A mitochondrial electron transport chain inhibitor

CAS_No

83-79-4

Molecular Weight

678.48

Purity

>98% by NMR

Storage

-20 centigrade

Targets

mirotubule

Molecular Formula

C 23 H 22 O 6

Chemical Name

(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-][1]benzopyran-6(6aH)-one

Solubility

DMSO (100 mM) or Ethanol (50 mM)

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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