SANT-1

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Cat No.

CEI-0664

Description

Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.

Appearance

White to off-white solid

Product Overview

A potent inhibitor of Sonic hedgehog (Shh) signaling

CAS_No

304909-07-7

Molecular Weight

543.54

Purity

>98% by NMR

Storage

-20 centigrade

Targets

SHH

Molecular Formula

C 23 H 27 N 27

Chemical Name

N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4- (phenylmethyl)-1-piperazinamine

Solubility

DMSO

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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