SB 203580

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Cat No.

CEI-0165

Description

SB 203580 can inhibit p38 MAPK with IC50 of 300 nM.

Alias

SB-203580, SB203580

CAS_No

152121-47-6

Molecular Weight

377.43

Purity

>99%

Storage

2 years at -20centigrade Powder

Synonyms

SB-203580, SB203580

Targets

p38 MAPK

Molecular Formula

C21H16FN3OS

Chemical Name

4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine

Solubility

DMSO 76 mg/mL, Water

In vitro

SB 203580 is a specific inhibitor of a MAP kinase, which can inhibit reactivating kinase (RK) with IC50 of 0.6 uM. SB 203580 suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of heat shock protein (HSP) 27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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