Semagacestat (LY450139)

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Cat No.

CEI-0208

Description

Semagacestat (LY450139) can inhibit gamma-secretase such as, Abeta42, Abeta40 and Abeta38, with IC50 of 10.9 nM, 12.1 nM and 12.0 nM.

CAS_No

425386-60-3

Molecular Weight

361.44

Purity

>99%

Storage

2 years at -20 centigrade

Targets

Abeta42, Abeta40, Abeta38

Molecular Formula

C19H27N3O4

Chemical Name

(S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide

Solubility

DSMO 72 mg/mL Water

In vitro

Semagacestat (LY450139) is a novel, smallmolecular weight inhibitor of gamma-secretase inhibitor. This inhibitor is developed for treating Alzheimers disease (AD), which is a progressive neurodegenerative disease.

In vivo

Oral administration of Semagacestat (1 mg/kg) to 5.5-month old APP-transgenic Tg2576 mice significantly ameliorates memory deficits on spatial working memory using the Y-maze task, which disappears after 8 days subchronic dosing.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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