SGX-523

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Cat No.

CEI-0059

Description

SGX523 can inhibit c-Met with IC50 of 4 nM.

CAS_No

1022150-57-7

Molecular Weight

359.41

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

c-Met

Molecular Formula

C18H13N7S

Chemical Name

6-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline

Solubility

DMSO 2 mg/mL Water

In vitro

SGX523 is a novel and selective APT- competitive inhibitor which can inhibit c-Met with IC50 of 4 nM. SGX523 is >1,000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays. SGX523 inhibited MET-mediated signaling, cell proliferation, and cell migration at nanomolar concentrations but had no effect on signaling dependent on other protein kinases. And SGX523 inhibit c-Met with the dose-dependent manner.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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