Simeprevir

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Cat No.

CEI-1527

Product Overview

Simeprevir is a potent inhibitor of HCV NS3/4A protease with Ki value of 0.36 nM. The hepatitis C virus (HCV) NS3/4A protease is a serine protease encoded by HCV and is responsible for cleavage at four sites of the HCV polyprotein. It is essential for viral replication. In Huh-7-Rep cells, Simeprevir inhibited HCV replication with EC50 of 7.8 nM. In the Huh7-Luc HCV genotype 1b replicon cell line, Simeprevir inhibited HCV replication with EC50 and EC90 values of 8 nM and 24 nM respectively in a dose dependent way. In ninety-two naive, HCV genotype 1-infected patients, treatment with Simeprevir (50 or 100 mg QD) for 12 or 24 weeks and peginterferon α-2a/ribavirin (PegIFNα-2a/RBV) for 24 or 48 weeks or PegIFN α-2a/RBV for 48 weeks lonely (PR48 group), RNA reductions in the 4 week were-5.2,-5.2 and-2.9 log10IU/mL for Simeprevir 50 mg combined, 100 mg combined and PR48 groups, respectively, which suggested Simeprevir reduced HCV RNA more rapidly and substantially. Also, Simeprevir increased the virologic response rate.

CAS_No

923604-59-5

Molecular Weight

749.96

Purity

0.9995

Storage

Store at -20°C

Synonyms

TMC435,TMC435350,TMC-435350,Simeprevir

Targets

HCV NS3/4A protease

Molecular Formula

C38H47N5O7S2

Solubility

Soluble in DMSO

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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