SIRT1 Inhibitor, EX-527

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Cat No.

CEI-0647

Description

A potent SIRT1 inhibitor (IC50 = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.

Appearance

Off-white solid

Product Overview

A SIRT1 inhibitor

CAS_No

49843-98-3

Molecular Weight

205.22

Purity

>97% by HPLC

Storage

-20 centigrade

Targets

SIRT1

Molecular Formula

C₁₃H₁₃ClN₂O

Chemical Name

EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Solubility

DMSO (>10 mg/ml) or H₂O (>10 mg/ml)

Shipping Conditions

Gel pack

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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