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Cat No.

CEI-0689

Description

Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.

Appearance

Beige solid

Product Overview

An ubiquitin E3 ligase inhibitor

CAS_No

432001-69-9

Molecular Weight

479.81

Purity

>90% by HPLC

Storage

-20 centigrade

Targets

RBX1

Molecular Formula

C18H13BrN2O4S2

Chemical Name

2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid

Solubility

DMSO ( 100 mM)

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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