Smo Antagonist, SA1

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Cat No.

CEI-0659

Description

A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC50 = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.

Appearance

Liquid

Product Overview

A Smoothened (Smo) antagonist

Molecular Weight

873.99

Purity

>95% by HPLC

Storage

-20 centigrade

Targets

SMO

Molecular Formula

C 26 H 29 FN 4 O 2

Chemical Name

3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide

Shipping Conditions

Gel pack

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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