Smo Antagonist, SA9

inquiry

Cat No.

CEI-0658

Description

SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC50 = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.

Appearance

Liquid

Product Overview

A Hedgehog (Hh) signaling pathway antagonist

Molecular Weight

860

Purity

>95% by HPLC

Storage

-20 centigrade

Targets

SMO

Molecular Formula

C 27 H 28 ClN 5 O 2

Chemical Name

3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide

Shipping Conditions

Gel pack

Name:

Email *

Phone:*

Company/Institution:

Country or Region:

Quantity:

Services & Products Interested *

Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

Products

Online Inquiry