S-Ruxolitinib (INCB018424)

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Cat No.

CEI-1074

Description

S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.

Abbr

S-Ruxolitinib (INCB018424)(JAK1, JAK2 )

Alias

JAK1A, JAK1B, JTK3

CAS_No

941685-37-6

Molecular Weight

306.37

Purity

0.9981

Storage

2 years -20 centigrade Powder 2 weeks4centigradein DMSO 6 months-80centigradein DMSO

Synonyms

JAK1A, JAK1B, JTK3

Targets

JAK1, JAK2

IC50

3.3 nM, 2.8 nM

Molecular Formula

C17H18N6

Chemical Name

1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-

Solubility

DMSO 61 mg/mL
Water 5 mg/mL
Ethanol 61 mg/mL

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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