SU-4312

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Cat No.

CEI-0976

Description

Potent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM ). Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM). Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease.

Abbr

SU-4312(KDR, PDGFRB)

Alias

1. 3-(4-Dimethylaminobenzylidene)-1, 3-dihydroindol-2-one 2. DMBI

Appearance

Orange powder

Product Overview

VEGFR; PDGFR inhibitor

CAS_No

5812-07-7

Molecular Weight

264.3

Purity

>98% (TLC); NMR (Conforms)

Synonyms

1. 3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one 2. DMBI

Targets

VEGFR, PDGFR

Molecular Formula

C17H16N2O

Solubility

May be dissolved DMSO (25 mg/ml)

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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