Sunitinib Malate (Sutent)

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Cat No.

CEI-0011

Description

Sunitinib Malate (Sutent) can inhibit VEGFR2 (Flk-1) and PDGFRbeta with IC50 of 80 nM and 2 nM.

Alias

SU-11248

CAS_No

341031-54-7

Molecular Weight

532.56

Purity

>99%

Storage

2 years at -20 centigrade

Synonyms

SU-11248

Targets

VEGFR2, PDGFRbeta

Molecular Formula

C22H27FN4O2.C4H6O5

Chemical Name

(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide,(S)-2-hydroxysuccinic acid

Solubility

DSMO 5 mg/mL Water

In vitro

By competing with ATP for binding within the intracellular domain of various wild-type and/or mutated receptor tyrosine kinases, sunitinib (SU11248) inhibit a list of tyrosine kinase including endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), platelet-derived growth factor receptors (PDGFR-alpha and PDGFR- beta ), fms-related tyrosine kinase 3 (FLT3), stem cell growth factor receptor KIT, and RET. As a multitargeted agent, sunitinib achieves a broader spectrum of activity than single-target agents including erlotinib and gefitinib. Sunitinib shows great inhibition to many cancer cells including gastrointestinal stromal tumours (GIST) and renal-cell carcinoma (RCC).

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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