TAK-715

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Cat No.

CEI-1114

Description

TAK-715 is a potent specific inhibitor of the p38α MAP kinase with an IC50 value of 7.1 nM. It inhibited TNF-α production by 87.6% in mice at 10 mg/kg, po and has potential for treatment of TNF-α mediated inflammatory diseases such as rheumatoid arthriti.

Abbr

TAK-715(MAPK14, TNF)

Alias

RP1-179N16.5, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, P38alpha

Product Overview

p38α MAP kinase

CAS_No

303162-79-0

Molecular Weight

399.51

Purity

> 95%

Stability

2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO

Storage

4 centigrade

Synonyms

RP1-179N16.5, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, P38alpha

Targets

p38alpha, TNF-alpha

IC50

7.1 nM, 48 nM

Molecular Formula

C24H21N3OS

Chemical Name

N-(4-(2-ethyl-4-m-tolylthiazol-5-yl)pyridin-2-yl)benzamide

Solubility

DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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