TAME Hydrochloride

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Cat No.

CEI-0400

Description

A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination.

Alias

N-p-Tosyl-L-arginine methyl ester hydrochloride

Appearance

Yellow solid

Product Overview

An anaphase-promoting complex/cyclosome (APC/C) inhibitor

CAS_No

1784-03-8

Molecular Weight

367.2

Purity

>90% by ⁵¹V-NMR

Storage

-20 centigrade

Synonyms

N-p-Tosyl-L-arginine methyl ester hydrochloride

Targets

anaphase-promoting complex/cyclosome (APC/C)

Molecular Formula

C 14 H 22 N 4 O 4 S.HCl

Solubility

DMSO or H₂O

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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