TAPI-1

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Cat No.

CEI-0680

Description

Inhibitor of TNF-α processing (IC50 = 100 nM), similar to TAPI-0, but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α (IC50 = 50-100 µM), APP (1-8 µM), IL6R (5- 10 µM), TNFRI (5 -10 µM), TNFRII (25 -50 µM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.

Alias

TNF protease inhibitor-0; C1

Appearance

White solid or clear, colorless film

Product Overview

An inhibitor of TNF-α processing

CAS_No

171235-71-5

Molecular Weight

826.98

Purity

>97% by TLC

Storage

-20 centigrade

Synonyms

TNF protease inhibitor-0; C1

Targets

TNF

Molecular Formula

C 26 H 37 N 5 O 5

Chemical Name

N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide

Solubility

DMSO or EtOH

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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