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Telatinib (BAY 57-9352)

Cat No.
CEI-0023
Description
Telatinib (BAY 57-9352)
CAS No.
332012-40-5
Molecular Weight
409.83
Purity
>99%
Storage
2 years at -20 centigrade
Targets
VEGFR2
Molecular Formula
C20H16ClN5O3
Solubility
No
In vitro
Telatinib (BAY 57-9352), a small molecule angiogenesis inhibitor, can potently inhibit VEGFR2, VEGFR3, c-Kit and PDGFRbeta with IC50 of 6 nM, 4 nM, 1 nM and 15 nM. Telatinib (BAY 57-9352) impairs vascular function, induces rarefaction, and causes hypertension. Telatinib can inhibit the autophosphorylation of VEGFR2 autophosphorylation with an IC50 of 19 nM, and telatinib also suppresses VEGF-dependent proliferation of human umbilical vein endothelial cells with an IC50 of 26 nM.
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