TG100-115

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Cat No.

CEI-0130

Description

TG100-115 can inhibit PI3K-gamma and PI3K-delta with IC50 of 83 nM and 235 nM.

CAS_No

677297-51-7

Molecular Weight

346.34

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

PI3K-gamma, PI3K-delta

Molecular Formula

C18H14N6O2

Chemical Name

6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine

Solubility

DMSO 9 mg/mL Water

In vitro

TG100-115 can inihbit PI3K-gamma and PI3K-delta with IC50 of 83 nM and 235 nM. TG100-115 has no effects on EC proliferation even at relatively high concentrations (up to 10 uM).

In vivo

TG100-115 can block histamine-induced permeability. In a rodent hindpaw model, TG100-115 strongly antagonized both the edema and leukocyte Infiltration. Blockade was seen with TG100-115 doses as low as 0.5 mg/kg and persisted over a period of several hours. But TG100-115 does not block VEGF-induced angiogenesis in vivo.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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