Tipifarnib (Zarnestra)

inquiry

Cat No.

CEI-0226

Description

Tipifarnib (Zarnestra) can inhibit farnesyltransferase with IC50 of 0.6 nM.

Alias

R115777

CAS_No

192185-72-1

Molecular Weight

489.4

Purity

>99%

Storage

2 years at -20centigrade Powder

Synonyms

R115777

Targets

farnesyltransferase

Molecular Formula

C27H22Cl2N4O

Chemical Name

(R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one

Solubility

DMSO 14 mg/mL Water

In vitro

As an Tipifarnib (formerly known as R-1 15777), an inhibitor of RAS farnesylation, for the potential treatment of neoplasia. Tipifarnib can inhibit farnesyltransferase with IC50 of 0.6 nM. Tipifarnib is an oral, very potent, and highly selective FTI (farnesyltransferase inhibitors) with a relatively low toxicity pro?le. FTIs function by competitively inhibiting the addition of a farnesyl moiety to several important signaling molecules 3 and thus target multiple pathways, including the RAS pathway implicated in the pathogenesis of solid and hematologic malignancies.

Name

Email *

Phone *

Company/Institution

Country or Region

Quantity

Services & Products Interested *

Project Description

Our Products Cannot Be Used As Medicines Directly For Personal Use.

Products

Online Inquiry