tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate

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Cat No.

CEGZ-6898

Description

tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate is a protected derivative of the macrocyclic chelator DOTA in which three of the four acetic acid arms are masked as tert-butyl esters. The single free carboxylic acid allows covalent conjugation to amines, peptides, antibodies, or other biomolecules, after which the tert-butyl esters are removed by acidolysis to restore full metal-chelating capacity.

Applications

Used as a key intermediate in the synthesis of DOTA-conjugated peptides, antibodies, and small molecules for radiometal labeling, magnetic resonance imaging contrast agent research, and targeted radionuclide studies.

Product Overview

DOTA is one of the most widely used macrocyclic ligands for forming highly stable complexes with lanthanides and radiometals. Its protected tri-tert-butyl ester form is the standard intermediate for preparing DOTA-based bifunctional chelating agents used in molecular imaging and targeted radiopharmaceutical research.

CAS_No

137076-54-1

Molecular Weight

572.7

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

DOTA tris(t-butyl ester); tri-tert-butyl 2,2′,2′′-(1,4,7,10-tetraazacyclododecane-1,4,7,10-triyl)triacetate with one free acetic acid arm; DOTA(tBu)₃

Molecular Formula

C28H52N4O8

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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