Tubacin

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Cat No.

CEI-0515

Description

Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC 50 = 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits α ;-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of α ;-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated α ;-tubulin deacetylation in mammalian cells.

Appearance

White to off-white solid

Product Overview

A potent HDAC6 inhibitor

CAS_No

537049-40-4

Molecular Weight

352.86

Purity

>98% by NMR

Storage

-20 centigrade

Targets

HDAC6

Molecular Formula

C41H43N3O7S

Chemical Name

N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide

Solubility

DMSO or EtOH

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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