Tubastatin A hydrochloride

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Cat No.

CEI-0994

Description

Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces -tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.

Abbr

Tubastatin A hydrochloride(HDAC6)

Alias

JM21, HD6

Appearance

White to off-white crystalline solid.

CAS_No

1310693-92-5

Molecular Weight

371.86

Storage

Store at or below -20 centigrade.

Synonyms

JM21, HD6

Targets

HDAC6

IC50

15 nM

Molecular Formula

C20H21N3O2 HCl

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Project Description:

For research and industrial use only, not for personal medicinal use.

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