Tubastatin A

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Cat No.

CEI-0514

Description

Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5 µM with near complete protection at 10 µM.

Appearance

Liquid

Product Overview

A selective HDAC6 inhibitor

CAS_No

1239262-52-2

Molecular Weight

263.26

Purity

>99% by HPLC

Storage

-20 centigrade

Targets

HDAC6

Molecular Formula

C₂₀H₂₁N₃O₂.HCl

Chemical Name

n-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide

Shipping Conditions

Gel pack

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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