UK-5099

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Cat No.

CEI-1565

Product Overview

UK-5099 is a potent inhibitor of the mitochondrial pyruvate carrier. The mitochondrial pyruvate carrier (MPC) facilitates pyruvate transport across the mitochondrial inner membrane and plays a critical role in carbohydrate, lipid and amino acid metabolism. UK-5099 (1 mM) completely blocked pyruvate uptake with Ki value of 49 μM. Also, UK-5099 decreased the overall efflux rate in a concentration-dependant way. In mitochondria isolated from S. Guttatum, UK-5099 (20 μM) inhibited pyruvate-dependent 02 consumption. In rat heart mitochondria, UK-5099 inhibited pyruvate oxidation with a non-linear inhibition kinetics. In glucagon-treated rats, UK-5099 inhibited pyruvate carboxylation and total pyruvate metabolism with a linear relationship. In rat liver and heart mitochondria, UK-5099 inhibited pyruvate-dependent 02 consumption with IC50 value of 50 nM.

CAS_No

56396-35-1

Molecular Weight

288.3

Purity

0.98

Storage

Store at -20°C

Synonyms

PF-1005023; UK5099; UK 5099; PF1005023; PF 1005023

Targets

MCTs; MPC

Molecular Formula

C18H12N2O2

Chemical Name

(E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid

Solubility

Soluble in DMSO > 10 mM

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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