UNC0638

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Cat No.

CEI-0486

Description

Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of <15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.

Appearance

White solid

Product Overview

Apotent G9a HMTase inhibitor

CAS_No

1255580-76-7

Molecular Weight

307.39

Purity

>98% by HPLC

Storage

-20 centigrade

Targets

EHMT2

Molecular Formula

C₃₀H₄₇N₅O₂

Chemical Name

2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

Solubility

DMSO ( 1mg/ml)

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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