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Vicriviroc Malate

Cat No.
CEI-0332
Description
Vicriviroc Malate
CAS No.
"541503-81-5
Molecular Weight
667.72
Purity
>99%
Storage
2 years at -20 centigrade
Targets
CCR5
Molecular Formula
C28H38F3N5O2.C4H6O5
Solubility
No
In vitro
Vicriviroc is nearly 6-fold less active than SCH-C (IC50 = 5.8 uM versus 1.1 uM) in attenuating hERG current among voltage-clamped L929 cells, indicating a reduced potential for cardiac effects. Vicriviroc inhibits MIP-1alpha induced migration of Ba/F3 cells stably expressing recombinant human CCR5, with IC50 of 0.91 nM. Vicriviroc is also highly active against a Clade G Russian isolate RU570 with EC90 of 16 nM, which is resistant to inhibition by SCH-C (EC90 > 1 uM). Vicriviroc could target an early step in the viral life cycle prior to reverse transcription and virion maturation, the targets of reverse transcriptase inhibitor and protease inhibitor, respectively.

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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