Vincristine Sulfate

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Cat No.

CSUB-0947

Description

Vincristine Sulfate, a dimeric Vinca alkaloid, has been shown to bind to Tubulin via a protein self association reaction. This compound acts as a Tubuiln inhibitor by binding to sites at the ends of microtubules, which regulate the inhibition of Tubulin dimer addition to microtubule ends. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis and cell cycle arrest at G2/M. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses. Vincristine Sulfate is an inhibitor of MAO. Vincristine Sulfate is also a substrate of PGP and CYP3A4.

Applications

A cell cycle arresting, apoptotic inducing alkaloid

Form

Solid

CAS_No

2068-78-2

Molecular Weight

923.04

Purity

>98%

Storage

Store at -20° C

Synonyms

22-Oxovincaleukoblastine Sulfate; Leurocristine Sulfate; Kyocristine; Lilly 37231; NSC 67574; Novopharm; Oncovin; Onkovin; VCR Sulfate; Vincasar PFS; Vincrisul

Molecular Formula

C46H56N4O10•H2SO4

MDL Number

MFCD00084729

Melting Point

300° C

Solubility

Soluble in water (25 mg/ml), ethanol, and methanol.

Substrates

PKA; CKII; PKCα

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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