Vismodegib (GDC-0449)

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Cat No.

CEI-0201

Description

Vismodegib (GDC-0449) can inhibit hedgehog and p-gp with 3 nM and 3 uM.

CAS_No

879085-55-9

Molecular Weight

421.3

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

Hedgehog, p-gp

Molecular Formula

C19H14Cl2N2O3S

Chemical Name

2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide

Solubility

DMSO 84 mg/mL Water

In vitro

GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide) is a potent inhibitor of the hedgehog pathway.Treating with GDC-0449 can lead to rapid (although transient) regression of the tumor and reduction of symptoms in metastatic medulloblastoma. GDC-0499 inhibited cell viability and induced apoptosis in three pancreatic cancer cell lines and pancreatic CSCs. This inhibitor also suppressed cell viability, Gli-DNA binding and transcriptional activities, and induced apoptosis through caspase-3 activation and PARP cleavage in pancreatic CSCs. GDC-0449-induced apoptosis in CSCs showed increased Fas expression and decreased expression of PDGFRalpha. And Bcl-2 was down-regulated whereas TRAIL-R1/DR4 and TRAIL-R2/DR5 expression was increased following the treatment of CSCs with GDC-0449.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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