Waglerin-1

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Cat No.

CEI-1180

Description

Waglerin-1 is a 22 amino acid peptide toxin isolated from the Southeast Asian snake Trimeresurus wagleri. Two other similar peptides named Waglerin-2 and 3 are isolated from the same snake species. Waglerin-1 selectively blocks the nAChRε subunit with an IC50 of 50 nM and is a potent blocker of muscle nAChR. Waglerin-1 is also a modulator of GABA(A) receptors with potentiating and suppressing effects. Its IC50 and EC50 value is 24 μM.

Abbr

Waglerin-1

Source

Synthetic peptide

Product Overview

A Potent Blocker of nAChR and a Modulator of GABA(A) Receptors

Molecular Weight

2520 Da

Purity

>99%

Storage

Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Synonyms

Waglerin-I, Wtx-1, Lethal peptide I

Targets

nAChR, GABA(A) receptors

Molecular Formula

C112H175N37O26S2

Amino Acid Sequence

GGKPDLRPCHPPCHYIPRPKPR

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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