WEHI-539

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Cat No.

CEI-1580

Product Overview

WEHI-539 is a small-molecule inhibitor of BCLXLwith an IC50 value of 1.1 nM. WEHI-539 was designed as a BCL-XLinhibitor with high affinity. It interacted the with the binding groove of BCL-XLwith a Kd value of 0.6 nM. In MEF cells lacking MCL-1, WEHI-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. In BCL-XLoverexpressed MEF cells, WEHI-539 showed EC50 value of 0.48 μM. WEHI-539 also significantly induced apoptosis of the platelets purified from mice. Besides that, WEHI-539 can not kill MEF cells lacking BAK because the cell death mediator BAK is regulated by BCL-XLand MCL-1.

CAS_No

1431866-33-9

Molecular Weight

583.72

Purity

0.98

Storage

Store at -20°C

Synonyms

WEHI539,WEHI 539

Targets

Bcl-xL

IC50

1.1 nM

Molecular Formula

C31H29N5O3S2

Chemical Name

5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid

Solubility

Soluble in DMSO

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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