WZ3146

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Cat No.

CEI-0026

Description

WZ3146

CAS_No

1214265-56-1

Molecular Weight

464.95

Purity

>99%

Storage

2 years at -20 centigrade

Targets

EGFR(L858R)

Molecular Formula

C24H25ClN6O2

Solubility

In vitro

As an irreversible inhibitor, WZ3146 can inhibit EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM, respectively. WZ3146 is profiled against Ba/F3 cells transformed with TEL fusions of BMX, BLK, JAK2 and JAK3. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR than WZ3146.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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