XAV939

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Cat No.

CEI-0675

Description

A Tankyrase (TNKS) inhibitor (IC50 = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the µ-catenin-dependent colon carcinoma cell line DLD-1.

Appearance

White to off-white solid

Product Overview

A Tankyrase (TNKS) inhibitor

CAS_No

284028-89-3

Molecular Weight

1429.15

Purity

>98

Storage

+4 centigrade

Targets

TNKS

Molecular Formula

C₁₄H₁₁F₃N₂OS

Chemical Name

3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one

Solubility

DMSO (10 mM) and water (50 mM)

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Project Description:

For research and industrial use only, not for personal medicinal use.

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