XL765

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Cat No.

CEI-0111

Description

As a dual inhibitor of mTOR/PI3k, XL765 shows inhibition to mTOR, p110alpha, p110beta, p110gamma and p110delta with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM.

Alias

SAR245409

CAS_No

1349796-36-6

Molecular Weight

599.66

Purity

>99%

Storage

2 years at -20 centigrade

Synonyms

SAR245409

Targets

MTOR, p110alpha, p110beta, p110gamma, p110delta

Molecular Formula

C31H29N5O6S

Chemical Name

Benzamide, N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-

Solubility

DSMO 15 mg/mL Water

In vitro

As a dual inhibitor of mTOR/PI3k, XL765 shows inhibition to mTOR, p110alpha, p110beta, p110gamma and p110delta with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM. XL765 treatment results in decreased cell viability in 13 PDA cell lines in a dose-dependent manner. XL765, a dual-target PI3K/mTOR inhibitor, inhibits cell growth and apoptosis in many more cell lines and at lower concentrations as compared to the PI3K-selective inhibitors XL147 and PIK90.

In vivo

The combination of XL765 (30 mg/kg) with chloroquine (50 mg/kg) results in significant inhibition of BxPC-3 xenograft growth in mice models, while XL765 alone at the same dose has no inhibitory effect.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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