Y-39983 dihydrochloride

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Cat No.

CEI-1588

Product Overview

Y-39983 dihydrochloride is a novel and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK. Y-39983 dihydrochloride has shown a selective inhibitor of Rho-associated coiled coil-forming protein kinase (ROCK) with IC50 values of 3.6nM, 0.42μM and 0.81μM for ROCK, PKC and CaMKII, respectively. Apart from these, Y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. In addition, Y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry. Moreover, Y-39983 lowered the intraocular pressure (IOP) in a dose-dependent fashion in the eyes of rabbits and monkeys.

CAS_No

173897-44-4

Molecular Weight

353.25

Purity

0.98

Storage

Store at-20°C

Targets

ROCK

Molecular Formula

C16H18Cl2N4O

Chemical Name

4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide; dihydrochloride

Solubility

Soluble in DMSO

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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