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ACC

Official Full Name
ACC
Background
Acetyl-CoA Carboxylase (ACC) regulates the metabolism of fatty acids. This enzyme catalzes the formation of Malonyl CoA through the irreversible carboxylation of acetyl CoA. There are two main isoforms of Acetyl-CoA carboxylase expressed in mammals, Acetyl-CoA carboxylase 1 (ACACA) and Acetyl-CoA carboxylase 2 (ACACB). ACACA has broad tissue distribution but is enriched in tissues critical for fatty acid sythesis such as adipose tissue. ACACB is enriched in tissues such as skeletal muscle and heart that are critical for fatty acid oxidation. The Acetyl-CoA Carboxylase enzymes are activated by Citrate, glutamate, and dicarboxylic acids and negatively regulated by long and short chain fatty acyl CoAs. Acetyl-CoA Carboxylase 1 is essential for breast cancer and prostrate cancer cell survival. Because of thier roles in fatty acid metabolism and oxidation, ACACA and ACACB are therapeutic targets for treating obesity and metabolic syndrome disorders.
Synonyms
ACAC; ACACA; ACC1; ACC; ACCA; acetyl-CoA carboxylase alpha; acetyl coenzyme A carboxylase; acetyl-CoA carboxylase

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-5813
EC No.EC 6.4.1.2
CAS No.9023-93-2
Source
CatalogNATE-0943
EC No.EC 6.4.1.2
CAS No.9023-93-2
SourceSf9 cells
CatalogNATE-0942
EC No.EC 6.4.1.2
CAS No.9023-93-2
SourceSf9 cells
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