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Native Arthrobacter ureafaciens α (2→3,6,8,9) Neuraminidase

Cat No.
NATE-0756
Description
Neuraminidase enzymes are glycoside hydrolase enzymes (EC 3.2.1.18) that cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. The viral neuraminidases are frequently used as antigenic determinants found on the surface of the Influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. Other homologs are found in mammalian cells, which have a range of functions.
Abbr
α-Neuraminidase, Native (Arthrobacter ureafaciens)
Alias
sialidase
Source
Arthrobacter ureafaciens
Applications
Neuraminidase is an important deglycosylation enzyme capable of cleaving all non-reducing unbranched N-acetylneuraminic and N-glycolylneuraminic acid residues by hydrolysis of α (2→6), α (2→3), α (2→8), and α (2→9) linkages (affinity in the order given). Branched sialic acids may also be cleaved with the use of high concentrations of enzyme and prolonged incubations. Desialylated glycoproteins may then be further characterized by treatment with various exoglycosidases resulting in partial or complete O-deglycosylation. SDS-PAGE and MALDI-TOF MS are typically utilized in purification, structural analysis, and sequencing process. These techniques also remove heterogeneity and charge from the glycoprotein.
Form
. Lyophilized powder
Enzyme Commission Number
EC 3.2.1.18
CAS No.
9001-67-6
Unit Definition
One unit will release 1 nmole of 4-methylumbelliferone from 2-(4-methylumbelliferyl) α-D-N-acetylneuraminic acid per minute at pH 5.5 at 37° C.
Storage
2-8°C
Synonyms
neuraminidase; sialidase; α-neuraminidase; acetylneuraminidase; exo-α-sialidase; EC 3.2.1.18; 9001-67-6
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Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-1683
EC No.EC 3.2.1.18
CAS No.9001-67-6
Source
CatalogNATE-1716
EC No.EC 3.2.1.18
CAS No.9001-67-6
SourceMicroorganism
CatalogNATE-0757
EC No.EC 3.2.1.18
CAS No.9001-67-6
SourceStreptococcus pneumoniae
CatalogNATE-0758
EC No.EC 3.2.1.18
CAS No.9001-67-6
SourceE. coli
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Realted Protocols
neuraminidase -Enzymatic Assay Protocol
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