Native Human Creatine Kinase MB Fraction

Cat No.

NATE-0141

Description

In the cells, the "cytosolic" CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). There are, therefore, three different isoenzymes:CK-MM, CK-BB and CK-MB. The genes for these subunits are located on different chromosomes:B on 14q32 and M on 19q13. In addition to those three cytosolic CK isoforms, there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form. The functional entity of the latter two mitochondrial CK isoforms is an octamer consisting of four dimers each.

Abbr

CKMB, Native (Human)

Alias

CK-MB; CKMB; Creatine Kinase MB

Source

Human heart

Species

Human

Applications

The MB isoenzyme of creatine kinase (MBCK) can be used as a diagnostic marker for acute myocardial infarction.

Form

liquid

Purity

> 70% (SDS-PAGE)

Concentration

> 0.5 mg/mL

Stability

−20°C

Buffer

Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.

Synonyms

CK-MB; CKMB; Creatine Kinase MB Fraction; Creatine Kinase MB

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