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Sialic Acid Aldolase from Escherichia coli K12, Recombinant


Cat No.
NATE-0475
Description
In enzymology, a N-acetylneuraminate lyase (EC 4.1.3.3) is an enzyme that catalyzes the chemical reaction:N-acetylneuraminate↔ N-acetyl-D-mannosamine + pyruvate. Hence, this enzyme has one substrate, N-acetylneuraminate, and two products, N-acetyl-D-mannosamine and pyruvate. This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. This enzyme participates in aminosugars metabolism.
Abbr
NALase, Recombinant (E. coli K12)
Alias
NPL; NALase; NANA lyase
Source
E. coli BL21
Species
Escherichia coli K12
Applications
Sialic acid aldolase can be used to synthesize unnatural sugars of C (6) to C (10) for the design of antagonists and inhibitors of glycoenzymes.
Product Overview
Sialic acid aldolases, or N-acetylneuraminate lyases, catalyze the reversible aldol cleavage of N-acetylneuraminic acid to form pyruvate and N-acetyl-D-mannosamine. In nature, N-acetylneuraminate lyase mainly occurs in pathogens.
Form
Lyophilized powder containing Tris-HCl and NaCl
Enzyme Commission Number
EC 4.1.3.3
Activity
> 3.0 units/mg protein
CAS No.
9027-60-5
Unit Definition
One unit will catalyze the formation of 1.0 μmol Neu-5-Ac from Man-N-Ac and pyruvate per minute at 37°C at pH 8.0.
Storage
−20°C
Synonyms
EC 4.1.3.3; Sialic Acid Aldolase; N-Acetylneuraminate lyase; N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming); N-acetylneuraminic acid aldolase; acetylneuraminate lyase; sialic aldolase; sialate lyase; N-acetylneuraminic aldolase; neuraminic aldolase; N-acetylneuraminate aldolase; neuraminic acid aldolase; N-acetylneuraminic acid aldolase; neuraminate aldolase; N-acetylneuraminic lyase; N-acetylneuraminic acid lyase; NPL; NALase; NANA lyase; acetylneuraminate pyruvate-lyase; N-acetylneuraminate pyruvate-lyase
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Catalog
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CatalogNATE-1850
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CatalogDIA-182
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CatalogNATE-0490
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Source
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Related Protocols
N-ACETYLNEURAMINIC ACID ALDOLASE -Enzymatic Assay Protocol
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