isocitrate dehydrogenase (NADP+)

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Cat No.

EXWM-0327

Description

Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm. The enzyme from some species can also use NAD+ but much more slowly.

Form

Liquid or lyophilized powder

Enzyme Commission Number

EC 1.1.1.42

CAS_No

9028-48-2

Storage

Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.

Synonyms

oxalosuccinate decarboxylase; oxalsuccinic decarboxylase; isocitrate (NADP) dehydrogenase; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific isocitrate dehydrogenase; NADP-linked isocitrate dehydrogenase; NADP-dependent isocitrate dehydrogenase; NADP isocitric dehydrogenase; isocitrate dehydrogenase (NADP-dependent); NADP-dependent isocitric dehydrogenase; triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase; NADP+-linked isocitrate dehydrogenase; IDH (ambiguous); dual-cofactor-specific isocitrate dehydrogenase; NADP+-ICDH; NADP+-IDH; IDP; IDP1; IDP2; IDP3

Reaction

isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+ (overall reaction); (1a) isocitrate + NADP+ = oxalosuccinate + NADPH + H+; (1b) oxalosuccinate = 2-oxoglutarate + CO2

Notes

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

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Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1103	Isocitrate dehydrogenase from Bacillus subtilis, Recombinant	EC 1.1.1.42	9028-48-2	Bacillus subtilis	Inquiry
NATE-1649	Mutant Isocitrate Dehydrogenase 1 R132H from Human, Recombinant			E. coli	Inquiry
NATE-0350	Native Porcine Isocitric Dehydrogenase (NADP)	EC 1.1.1.42	9028-48-2	Porcine heart	Inquiry
NATE-0351	Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant	EC 1.1.1.42	9028-48-2	Pichia pastoris	Inquiry

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