MDL 28170

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Cat No.

CEI-0416

Description

A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation.

Alias

Z-Val-Phe-CHO; Carbobenzoxy-valinyl-phenylalaninal; Calpain Inhibitor III

Appearance

White to off-white solid

Product Overview

A potent calpain and cathepsin B inhibitor

CAS_No

88191-84-8

Molecular Weight

628.81

Purity

>98% by HPLC

Storage

-20 centigrade

Synonyms

Z-Val-Phe-CHO; Carbobenzoxy-valinyl-phenylalaninal; Calpain Inhibitor III

Targets

calpain, cathepsin B

Molecular Formula

C 22 H 26 N 2 O 4

Solubility

DMSO

Shipping Conditions

Gel pack

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1706	Cathepsin B from Human, recombinant	EC 3.4.22.1	9047-22-7	E. coli	Inquiry

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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