Native Almond α (1-3,4) Fucosidase

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Cat No.

NATE-0260

Description

Tissue alpha-L-fucosidase is an enzyme that in humans is encoded by the FUCA1 gene. Alpha-Fucosidase is an enzyme that breaks down fucose. Fucosidosis is an autosomal recessive lysosomal storage disease caused by defective alpha-L-fucosidase with accumulation of fucose in the tissues. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form; coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longer surviving form; and an unusual spondylometaphyseoepiphyseal dysplasia in yet another form.

Abbr

FUCA, Native (Almond)

Alias

FUCA1; FUCA

Source

Almond meal

Species

Almond

Form

Lyophilized from 50 mM sodium acetate, 3 mg/ml bovine serum albumin (pH 5.0).

Activity

>1.5 U/mg

Molecular Weight

111.5 kD

Purity

No protease activity was detectable after incubation of the enzyme with 0.4% Resorufin-labeled Casein for 18-24 hours at 37°C. Assays for exoglycosidase contaminants consist of extended incubations with the appropriate substrates. Lot-specific results are reported on the Certificate of Analysis.

Specificity

The enzyme cleaves non-reducing α (1-3 or 1-4)-linked terminal fucose residues.

Optimum pH

pH 5.0

Stability

After reconstitution with the incubation buffer supplied with the enzyme, >85% of the original activity is observed after two months at 2–8°C. In the buffer solution at 37°C, the half-life is approximately 80 hours.

Storage

Shipped on ice pack for next day delivery. Store at -20°C. Store lyophilized enzyme at-20°C. Enzyme reconstituted with the provided reaction buffer is stable at 2-8°C for at least two months and may be stored at-20°C for at least six months. Avoid repeated freeze/thaw cycles.

Buffer

WS0062 5x Reaction Buffer (250 mM sodium acetate, pH 5.0)

Synonyms

α (1-3,4) Fucosidase; alpha-L-fucosidase; Alpha-Fucosidase; FUCA1; FUCA

"FUCA" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1258	α(1-2) Fucosidase from Xanthomonas manihotis, Recombinant			E. coli	Inquiry
NATE-0266	Native Bovine α-L-Fucosidase	EC 3.2.1.51	9037-65-4	Bovine kidney	Inquiry
NATE-0749	Native environmental DNA α-Fucosidase	EC 3.2.1.51	9037-65-4	Proprietary environmental DNA	Inquiry
NATE-0261	Native Bovine α (1-2,3,4,6) Fucosidase			Bovine kidney	Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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