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FUCA


Official Full Name
FUCA
Background
Alpha-Fucosidase is an enzyme that breaks down fucose. Fucosidosis is an autosomal recessive lysosomal storage disease caused by defective alpha-L-fucosidase with accumulation of fucose in the tissues. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form; coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longer surviving form; and an unusual spondylometaphyseoepiphyseal dysplasia in yet another form.
Synonyms
α-L-fucoside fucohydrolase; Alpha-Fucosidase; FUCA1; FUCA; EC 3.2.1.51

Catalog
Product Name
EC No.
CAS No.
Source
Price
CatalogEXWM-3914
ProductNameα-L-fucosidase
EC No.EC 3.2.1.51
CAS No.9037-65-4
Source
CatalogNATE-1264
EC No.
CAS No.
SourcePichia pastoris
CatalogNATE-1258
EC No.
CAS No.
SourceE. coli
CatalogNATE-0260
EC No.
CAS No.
SourceAlmond meal
CatalogNATE-0261
EC No.
CAS No.
SourceBovine kidney
CatalogNATE-0264
EC No.EC 3.2.1.51
CAS No.9037-65-4
SourceE. coli
CatalogNATE-0259
EC No.EC 3.2.1.51
CAS No.9037-65-4
Source
CatalogNATE-0263
EC No.EC 3.2.1.51
CAS No.9037-65-4
SourceXanthomonas sp.
CatalogNATE-0262
EC No.EC 3.2.1.51
CAS No.9037-65-4
SourceXanthomonas sp.
CatalogNATE-0749
EC No.EC 3.2.1.51
CAS No.9037-65-4
SourceProprietary env...
CatalogNATE-0266
EC No.EC 3.2.1.51
CAS No.9037-65-4
SourceBovine kidney
Related Services
Related Protocols
alfa-L-fucosidase -Enzymatic Assay Protocol
Related Reading

α-L-Fucosidase (AFU) is a kind of lysosomal acid hydrolase. In 1980, French scholar Deugnier et al. found that AFU has good sensitivity in diagnosing hepatocellular carcinoma, and the positive rate is high. It is the positive rate of AFP. More than three times, it is of great value in the diagnosis of AFP-negative cases and small cell liver cancer, and is a useful indicator for the diagnosis of early primary liver cancer. It has been confirmed by many researches.

Structure of alpha-L-fucosidase. Figure 1. Structure of alpha-L-fucosidase.

Biochemical properties

AFU is mainly involved in the catabolism of various fucosyl-containing glycolipids, glycoproteins, mucopolysaccharides and other macromolecular substances. It is widely present in lysosomes and body fluids of various tissues of the human body. Serum, urine, saliva, tears and other specimens are acceptable. The specimens should be clarified and stored at 4°C for 3 days, and at -20°C for 3 months. Avoid repeated freezing and thawing. Hemolysis, jaundice, hyperlipidemia, and contaminated specimens seriously affect the results.

Clinical significance

Reference

  1. Occhiodoro T.; et al. Human alpha-L-fucosidase: complete coding sequence from cDNA clones. Biochem. Biophys. Res. Commun. 1989, 164 (1): 439–45.

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