Native Human Proteinase 3

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Cat No.

NATE-0620

Description

Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis (formerly known as "Wegener's granulomatosis").

Abbr

PR3, Native (Human)

Alias

PRTN3; PR3

Source

Human Neutrophils

Species

Human

Form

Liquid

Enzyme Commission Number

EC 3.4.21.76

Activity

Typically > 0.1 U/mg protein

CAS_No

128028-50-2

Purity

> 96% (SDS-PAGE)

Unit Definition

One unit will hydrolize one micromole of Methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37°C and pH 7.5.

Storage

-20°C

Pathway

C-MYB transcription factor network, organism-specific biosystem

Function

enzyme binding; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Synonyms

PRTN3; proteinase 3; ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3; EC 3.4.21.76

"PRTN3" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
EXWM-4168	myeloblastin	EC 3.4.21.76	128028-50-2		Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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