Phosphodiesterase 5A1 from Human, Recombinant

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Cat No.

NATE-0527

Description

PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis.

Abbr

PDE5A, Recombinant (Human)

Alias

PDE5A1; PDE5A

Source

Sf9 cells

Species

Human

Applications

Phosphodiesterase (PDE) is an enzyme that is used to breaks phosphodiester bonds. PDE5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. PDE5 is used to find novel PDE5 inhibitors.

Product Overview

N-terminal GST-tagged 126 kDa full-length protein

Form

Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN 20 and 3 mM DTT

Molecular Weight

126 kDa

Unit Definition

One unit will convert 1.0 picomole of 3',5'-cGMP to 5'-GMP per minute at pH 7.4 at 37°C.

Storage

−70°C

Pathway

Hemostasis, organism-specific biosystem; Nitric oxide stimulates guanylate cyclase, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; cGMP effects, organism-specific biosystem

Function

3,5-cyclic-GMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cGMP binding; hydrolase activity; metal ion binding; nucleotide binding; zinc ion binding

Synonyms

CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1

"Phosphodiesterase" Total Products Page

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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